Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.
In subanalyses, subjects whoever couples made use of condoms 100 percent of time was split up into two categories on such basis as its answers so you can practical question “Performed their partner’s dick ever reach the hole of the vagina instead of a great condom?” In the event the victims usually responded “no” for each act away from genital gender into the 7-few days period, these were coded because the that have had “no genital get in touch with as opposed to an effective condom.” Analyses was basically performed since described significantly more than, which have four types of the fresh volume away from condom play with (100 percent without any genital get Sober dating sites in touch with instead of a condom, 100 % with many or an unidentified frequency of genital contact in the place of an effective condom, and you may about three organizations less than completely, since revealed significantly more than).
Likewise, Cox proportional-threats designs were used to choose exposure factors into detection regarding incident cervical squamous intraepithelial sores during the eight weeks before a given Pap take to (based on a previous observation that the majority of lesions exists after experience problems 23 ). A good 51-go out slowdown before every check out is actually integrated due to the fact 51 months is the latest quickest seen interval involving the time a lady basic got gender together with day from identification out-of a case lesion in this study. Research to have particularly sufferers was indeed censored following the very first identification regarding an incident lesion.
Results
New imply (±SD) chronilogical age of the latest 82 victims at enrollment was 19.3±0.eight age. The fresh new victims done 709 check outs. This new indicate realize-upwards big date is actually 33.9±11.8 days, the fresh new suggest level of check outs for each lady is actually 8.6±2.9, in addition to median time between check outs are 4.step one weeks. Log study were ninety.7 percent over, and you will condom data was submitted towards 99.3 per cent away from weeks you to sex are claimed.
Desk 2
The new twelve-week collective chance out-of a primary HPV issues immediately following first sex is actually 37.dos per cent (95 percent count on period, twenty-seven.dos so you can forty two.cuatro per cent). A total of 126 event method of-certain infections was indeed identified when you look at the 40 lady when they very first got intercourse ( Dining table dos ). Incident attacks had been recognized within the about three girls just before they advertised that have sex the very first time, including you to definitely positive to have HPV types of 51, one getting HPV sorts of 6, plus one having HPV versions 40, 61, and 66. New 24-month collective occurrence out-of cervical squamous intraepithelial lesions try fifteen.0 % (95 percent count on interval, 8.step 3 to twenty six.dos per cent).